Appropriate for
Patients suffering from chronic or recurrent pain in tendons, ligaments, or joint capsules (tendinopathies, plantar fasciitis, epicondylitis, instability).
Prolotherapy is a regenerative infiltrative therapy that stimulates the body’s natural repair processes through micro-injections of a hypertonic glucose solution into weakened tendons, ligaments, and joint capsules. It triggers a controlled inflammatory response that promotes new collagen production, improving strength, stability, and joint functionality. At IMAGE Regenerative Clinic, prolotherapy is performed by Dr. Moscati, specialist in regenerative and orthopedic medicine, as part of the “Repair before Replace” philosophy, aimed at preventing or delaying invasive surgical treatments.
Patients suffering from chronic or recurrent pain in tendons, ligaments, or joint capsules (tendinopathies, plantar fasciitis, epicondylitis, instability).
Suitable from late adolescence to mature age.
15–30 minutes including preparation and local anesthesia.
3–6 sessions, spaced every 2–4 weeks.
To be performed exclusively by a qualified physician in a sterile environment. Avoid excessive strain for 48–72 hours after treatment and follow any prescribed rehabilitation plan.
Select your preferred time and date
Prolotherapy is a regenerative medical technique designed to reactivate the body’s natural ability to repair connective tissues.
It stems from the understanding that many musculoskeletal conditions, such as chronic tendinopathies, ligament laxity, joint instability, or connective tissue degeneration — often result not only from trauma but from a slow or incomplete healing process.
Over time, weakened tendons and ligaments lose their natural tension, leading to micro-instability, pain, and reduced mobility.
Prolotherapy acts directly on this mechanism by inducing a controlled, therapeutic inflammatory response: micro-injections of a hypertonic glucose solution locally stimulate the recruitment of reparative cells, fibroblasts, and growth factors.
The outcome is an increase in collagen synthesis and a progressive strengthening of tendons and ligaments, producing long-lasting stability and pain relief.
Rather than masking the symptom, this treatment addresses the biological cause, activating a physiological regenerative response that restores balance and structural integrity where the body had lost support.
The procedure begins with a specialized orthopedic and regenerative consultation, during which the physician evaluates the location of pain, the degree of damage, and joint mobility.
When indicated, the assessment may include a musculoskeletal ultrasound to precisely locate the area to be treated.
In the clinic, Dr. Moscati, regenerative orthopedic specialist at IMAGE Regenerative Clinic, performs targeted micro-injections of the glucose solution (typically 15–25%) directly at the ligament or tendon insertion points.
The therapeutic effect is not due to the substance itself but to the mechanical and biological stimulation it provokes:
the controlled irritation recruits reparative cells and growth factors, enhances local vascularization, and promotes
Select your preferred time and date
No. Local anesthesia is used, and discomfort is minimal, comparable to a standard injection.
Within 2–4 weeks, with progressive improvement after each session.
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Each session lasts about 20–30 minutes, requires no general anesthesia or hospitalization, and allows a quick return to normal daily activities.
A mild soreness or sense of tightness may occur in the hours following the procedure, a natural and temporary sign of the regenerative process at work.
In the weeks after treatment, the tissues undergo a gradual remodeling and strengthening process.
Joint stability improves, pain progressively diminishes, and functionality is restored.
In cases of chronic pain or micro-instability, prolotherapy often enables patients to reduce or discontinue anti-inflammatory medication and to delay or avoid surgery.
To maximize its effectiveness, the IMAGE protocol includes an integrated rehabilitation program with physiotherapy and muscle strengthening aimed at consolidating the results and preventing recurrence.
The goal is not merely to remove pain, but to restore biological integrity, giving patients lasting comfort, freedom of movement, and joint performance.
At IMAGE Regenerative Clinic, Dr. Moscati incorporates prolotherapy into personalized orthopedic regenerative medicine protocols, often as an intermediate step between physiotherapy and Lipogems, in cases of:
Prolotherapy represents an intelligent intermediate solution between conservative care and surgery.
It is a biological, minimally invasive, and drug-free method grounded in the philosophy of “repair before replace”, encouraging the body to heal before resorting to replacement.
Safe and performed in an outpatient setting, this therapy fully embodies the vision of IMAGE Regenerative Clinic, where regenerative medicine is not just a medical discipline but a language of the body that renews itself.
Restoring movement, strength, and fluidity means not only healing a structure, but re-harmonizing a living system, the body in its functional and aesthetic integrity.
Several months on average, depending on the treated area and individual tissue response.
Yes. In mild or moderate cases, prolotherapy can often prevent or delay surgical intervention.
Yes. When performed by qualified medical professionals in a sterile environment, the procedure is considered very safe. Side effects are rare and temporary.