Understanding the Science Behind Lipogems® Technology
Carlo Tremolada, Carlo Ventura, Milford Graves · US Patent Application Publication · 2015
Your own fat tissue contains powerful healing cells
If you're exploring regenerative medicine options, you may have heard about treatments using stem cells from your own body. This patent document describes the scientific foundation behind Lipogems® technology, which processes your own fat tissue to concentrate helpful healing cells.
Fat tissue (also called adipose tissue) is a rich source of regenerative cells. These include mesenchymal stem cells (cells that can develop into various tissue types) and pericytes (helper cells that support blood vessel health). The Lipogems® process keeps these cells in their natural environment rather than growing them in a laboratory.
No lab expansion needed—cells stay in natural form
One key advantage described in this patent is that the processed tissue is "non-expanded." This means the cells are not grown or multiplied in a laboratory setting. Instead, they remain in their original, natural state. This approach preserves the tissue's vascular-stromal fraction—the network of blood vessels and supporting cells that help healing occur.
By avoiding laboratory expansion, the process:
Keeps cells in their natural protective environment
Maintains the natural balance of cell types
Allows for same-day procedures using your own tissue
Heart sound vibrations may enhance cell potential
The patent describes a fascinating discovery about how sound vibrations might influence stem cells. The inventors observed that heart sounds—the rhythmic beating present from the earliest days of embryonic development—may help optimize how stem cells function.
Since the heart begins forming just seven days after conception, its vibrations accompany all human development. The researchers theorize that exposing adult stem cells to heart sound vibrations could help enhance their regenerative potential. This represents an innovative approach to improving treatment outcomes without complex genetic engineering.
Technology uses your own tissue for safety
The Lipogems® approach is "autologous," meaning it uses tissue from your own body. This is significant because:
There is no risk of rejection since the cells are yours
No donor tissue is needed
The procedure can often be completed in a single visit
The patent describes a specialized device that gently processes fat tissue collected through a minimally invasive procedure. This processing concentrates the beneficial cells while keeping them protected in their natural tissue structure.
Avoiding ethical concerns of embryonic cells
Unlike embryonic stem cells, which raise ethical questions, this technology uses adult stem cells from your own fat tissue. Adult stem cells are "multipotent," meaning they can develop into several (though not all) cell types. They naturally help maintain and repair tissues throughout your body.
The patent notes that while embryonic cells have broader potential, the ethical issues surrounding their use have led researchers toward adult stem cell solutions. The Lipogems® technology represents a practical, ethical approach that harnesses your body's own healing resources.
What this means for your treatment decision
This patent establishes the scientific and technical foundation for Lipogems® procedures. While patents describe technology rather than clinical trial results, this document confirms several important points for patients considering treatment:
The technology preserves natural healing cells from your own fat tissue
Processing is designed to concentrate beneficial stem cells and pericytes
The approach avoids laboratory cell expansion, keeping tissue in its natural state
Innovative techniques may help optimize cell function for better outcomes
If you're considering Lipogems® treatment for tissue regeneration, this foundational science explains how the technology works to support your body's natural healing processes. Discuss with your healthcare provider whether this approach might be appropriate for your specific condition.
Source: Tremolada et al., US Patent Application Publication, 2015.
Original Publication
Method and Device for Preparing Non-Embryonic Stem Cells
Carlo Tremolada, Carlo Ventura, Milford Graves · US Patent Application Publication · 2015
The invention relates to a process for preparing a non-expanded tissue derivative enriched in stem and multipotent elements (pericytes and/or mesenchymal stem cells) or for preparing non-embryonic stem cells from tissue samples. The key innovation involves subjecting the tissue derivative or cells to vibrations derived from heart sounds to control the degree of differentiation of stem and multipotent elements and optimize their potency. The process addresses limitations of current stem cell technologies by avoiding complex genetic engineering techniques required for induced pluripotent stem cells while enhancing the differentiation potential of adult stem cells beyond their typical multipotent capacity. The invention is based on the discovery that heart sounds, which are continuously present from early embryonic development (cardiogenesis begins at day seven in humans), may act as an orchestrating function affecting cell differentiation across all tissues. By exposing non-embryonic stem cells to heart sound vibrations, the process aims to reprogram or enhance their potency without genetic manipulation. The invention also encompasses a device for performing the process, stem cells produced by this method, and pharmaceutical applications for animal tissue regeneration. This approach offers a potentially simpler alternative to genetic reprogramming for obtaining stem cells with optimized differentiation potential for clinical applications.