Understanding the Lipogems® Patent: A Gentler Way to Process Your Body's Own Fat for Healing

Carlo Tremolada · United States Patent Application Publication · 2019

New Method Keeps More Healing Cells Intact

This patent describes the technology behind Lipogems®, a method for preparing your own fat tissue for transplantation. Traditional approaches often damage the delicate cells needed for healing. The Lipogems® technique was designed to overcome these problems by using a gentler process that preserves more of your body's natural regenerative cells.

Why Traditional Fat Processing Methods Fall Short

Older techniques for preparing fat tissue have several drawbacks. Centrifugation (spinning at high speeds) and mechanical blenders can break open fat cells. This releases oil that can cause inflammation and increase infection risk. These methods also waste a significant portion of the collected tissue, sometimes making more than half unusable. Additionally, older processes require multiple transfers between containers, increasing the chance of contamination.

Lipogems® Uses Gentle Washing Instead of Harsh Spinning

The patented Lipogems® method takes a different approach:

  • Gentle micro-fragmentation: Instead of cutting blades or high-speed spinning, the tissue is processed through a special washing system

  • Closed sterile environment: The fat stays protected from air and outside contamination throughout the entire process

  • Oil removal through density separation: Unwanted oils and fluids naturally separate and drain away without damaging healthy cells

  • Minimal handling: Fewer steps mean less chance for contamination or cell damage

The Technology Preserves Your Body's Natural Healing Structures

The Lipogems® system creates an emulsion (a mixture of the washing solution and tissue) using gentle stirring. This allows waste products like blood, oils, and cell fragments to separate naturally based on their weight. The result is cleaned, micro-fragmented adipose tissue (specially processed fat) that keeps its natural structure intact. This is important because the tissue contains pericytes (cells that support blood vessel healing) and mesenchymal stem cells that work best when their natural environment is preserved.

Designed for Volume Restoration and Skin Quality

The patent specifically mentions two key applications for this prepared tissue:

  • Treating volume deficiencies: Restoring fullness to areas that have lost tissue

  • Improving skin quality: Enhancing the health and appearance of skin through biological stimulation

Because the processing is gentle and maintains sterility, the prepared tissue can be used in a doctor's office setting rather than requiring a full operating room. This makes the procedure more accessible and convenient for patients.

A Safer, More Efficient Approach to Regenerative Treatment

The Lipogems® technology addresses the main concerns with earlier fat-processing methods. By keeping the tissue in a closed system from start to finish, contamination risk drops significantly. The gentle processing means less tissue is wasted, so smaller amounts need to be collected from your body. And because harmful oils are thoroughly removed, there is reduced risk of inflammation or rejection after injection.

This patented method represents an important advancement in autologous (using your own tissue) regenerative medicine. It allows doctors to harness your body's own healing potential while minimizing the drawbacks of older preparation techniques.

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Source: Tremolada et al., United States Patent Application Publication, 2019.

Original Publication

Method for Preparing Tissue, Particularly Adipose Tissue, for Transplantation from Lobular Fat Extracted by Liposuction

Carlo Tremolada · United States Patent Application Publication · 2019

A method of preparing adipose tissue for transplantation from lobular fat extracted by liposuction is described. The extracted fat consists of a fluid component comprising an oily component, blood component and/or sterile solutions, and a solid component comprising cell fragments, cells and one or more cell macroagglomerates of heterogeneous size. The method is characterized by at least one step of forming an emulsion of the fluid component in a sterile washing solution by means of active and/or passive stirring, followed by discharging the emulsion through a density gradient. This approach addresses limitations of prior art techniques, including the Coleman lipostructure method and mechanical fragmentation using blenders, which involve centrifugation that causes substantial adipocyte rupture and oil release. These conventional methods result in considerable amounts of unusable lipoaspirate due to oil contamination and cell damage, requiring multiple liposuction sessions and increased patient discomfort. The method also aims to reduce the risk of infections and rejections associated with oil presence in the biological filler, while minimizing contact with non-sterile surfaces and air. The invention further relates to treating body and face volume deficiencies, improving skin trophism, and providing biological stimulation using the prepared adipose tissue.

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