
Regenerative Medicine
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The knee represents one of the most complex and stressed joints in the human body, acting as a sophisticated natural shock absorber. At IMAGE REGENERATIVE, we dedicate ourselves to treating joint pathologies through an approach that favors biology over mechanical replacement.
Many people suffering from chronic pain seek solutions for post-injury recovery with regenerative techniques precisely to avoid invasive procedures.
Thanks to Professor Carlo Tremolada's vision, we have introduced cutting-edge protocols based on orthopedic Lipogems®, a patented technology that uses the potential of the patient's own adipose tissue to stimulate tissue repair processes and improve joint function.
Articular cartilage is an elastic and resistant connective tissue, devoid of blood vessels and nerves, that covers the bone ends inside the knee. Its primary function is to facilitate smooth sliding between femur and tibia, reducing friction during movement and distributing loads during daily activities such as walking, running, or climbing stairs.
Since this tissue has no spontaneous self-regeneration capacity due to the lack of direct blood supply, every lesion or degenerative process tends to progress over time. Maintaining cartilage integrity means preserving mobility and preventing the onset of chronic inflammation that can seriously compromise quality of life.
Deterioration of the articular surface can derive from multiple factors acting individually or in combination.
Acute trauma, typical of athletes, often causes focal cartilage lesions due to violent impacts or improper twisting. There is also progressive wear related to aging, known as osteoarthritis, where the protective layer gradually thins.
Factors such as overweight exert excessive mechanical pressure on articular surfaces, accelerating degradative processes. Axial deviations of the limb, such as varus or valgus knee, also determine an unbalanced load that prematurely wears specific areas of cartilage, leading to premature loss of movement fluidity.
Recognizing early signs of knee distress is essential for successful intervention. The main symptom is pain, which initially appears only under stress but, as the lesion progresses, can manifest even at rest. Patients often report a sensation of morning stiffness or after long periods of inactivity, which improves slightly with movement.
Joint swelling, due to accumulation of synovial fluid in response to inflammation, is another common indicator. In some cases, joint noises, similar to creaking or sudden mechanical blocks, may be heard, signaling the presence of cartilage fragments or a bone surface that is now irregular and no longer protected.
For years, the standard approach to cartilage problems has included the use of conservative therapies such as hyaluronic acid injections. Although these may offer temporary relief by lubricating the joint, they act exclusively on the symptom and not on tissue regeneration.
Hyaluronic acid is absorbed by the body in a short time, requiring repeated cycles without ever resolving the structural cause of damage. Other classic options include the use of anti-inflammatory drugs or, in more severe cases, surgical intervention for prosthesis insertion. However, prosthetic surgery is an invasive operation with long recovery times and the need, over time, for possible mechanical revisions.
As an alternative to symptomatic treatments that last a short time, IMAGE REGENERATIVE proposes the excellence of regenerative medicine. The core of our intervention is the Lipogems® system, a technology that allows harvesting a small amount of adipose tissue from the patient, processing it in a minimally invasive way, and reinjecting it into the damaged joint.
Adipose tissue is a precious source of pericytes and mesenchymal precursors, which possess a natural ability to reduce inflammation and favor an ideal biochemical environment for cartilage stability.
Unlike traditional injections, this approach aims to preserve the original joint, exploiting the body's biological capabilities to improve natural lubrication and tissue health.

Feature | Traditional Injections (Hyaluronic Acid) | Regenerative Medicine (Lipogems®) |
Mechanism of action | Temporary symptomatic lubrication | Regeneration of tissue microenvironment |
Substance origin | Synthetic or bio-fermentative | Autologous (patient's own tissue) |
Duration of effect | Limited to a few months | Long-lasting and biological results |
Primary objective | Momentary friction reduction | Healing and joint maintenance |
The procedure with Lipogems® technology is performed in day hospital and lasts approximately one hour. The procedure begins with a mini-harvest of adipose tissue, usually from the abdomen or flanks, performed under local anesthesia.
The harvested fat is then instantly processed through a closed-circuit system that fragments and purifies it from oily and inflammatory residues, keeping vascular niches and regenerative cells intact. Subsequently, the obtained product is injected with surgical precision inside the knee.
Since exclusively autologous material is used, the risk of rejection is non-existent and the body immediately recognizes the tissue as its own, initiating the process of stabilization of the joint compartment.
The post-treatment course is significantly faster compared to traditional surgery. The patient can usually walk independently shortly after the procedure, although a period of relative rest is recommended for the first days to allow the injected tissue to stabilize. Benefits begin to manifest in the following weeks, with a progressive reduction in pain and an increase in movement fluidity.
Regenerative medicine does not only offer symptomatic relief, but works in depth to delay or completely avoid the need for a prosthesis. Patients gradually return to their daily and sports activities with a joint that responds more elastically and less inflamed to mechanical stimuli.
The biological repair occurs through the infiltration of the patient's micro-fragmented adipose tissue. This tissue acts as a natural scaffold that releases growth factors and cells with regenerative capabilities, improving the health status of existing cartilage and reducing chronic inflammation.
The regenerative procedure with the Lipogems® method is quick and generally concludes within sixty minutes. Being performed under local anesthesia and on an outpatient basis, it allows the patient to return home the same day, avoiding the long hospital stays typical of classic orthopedic procedures.
The most advanced techniques concern autologous regenerative medicine. Beyond Lipogems®, which represents excellence for the quality of tissue obtained, there are protocols that integrate targeted bio-stimulations to optimize the joint microenvironment and preserve the original anatomy of the knee without the use of artificial components.
When cartilage is seriously worn, it is essential to act promptly to protect the underlying bone. Instead of limiting to temporary lubricants, the regenerative approach allows stabilizing the joint, eliminating pain and improving mobility, representing a valid alternative to prosthetic replacement.
Do you suffer from joint pain and want to avoid invasive surgery?
Contact IMAGE REGENERATIVE to book a specialist visit and assess whether you are the ideal candidate for the Lipogems® protocol.
regenerative-medicineAt IMAGE REGENERATIVE, we offer a multidisciplinary approach that redefines the concept of healing, integrating the most modern discoveries in regenerative medicine with continuous care pathways.
regenerative-medicineThe knee represents one of the most complex and stressed joints in the human body, acting as a sophisticated natural shock absorber.
regenerative-medicineThe approach to treating degenerative pathologies has undergone a radical transformation thanks to discoveries in biotechnology applied to health.
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